期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 23, 期 1, 页码 7-15出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3147
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资金
- UK Medical Research Council [MC_UP_A022_1007]
- Stanford University
- US National Institutes of Health [1R01GM115968-01]
- MRC [MC_UP_A022_1007] Funding Source: UKRI
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM115968] Funding Source: NIH RePORTER
- Medical Research Council [MC_UP_A022_1007] Funding Source: researchfish
Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA, insufficient availability of charged tRNAs and genetic errors. All organisms have evolved mechanisms to recognize stalled ribosomes and initiate pathways for recycling, quality control and stress signaling. Here we review the discovery and molecular dissection of the eukaryotic ribosome-associated quality-control pathway for degradation of nascent polypeptides arising from interrupted translation.
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