期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 23, 期 12, 页码 1053-1060出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3326
关键词
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资金
- NIH [GM079180, HL059596]
- William Bowes Neurogenetics Fund
- Uehara memorial foundation (Japan)
Endogenous biological rhythms with approximately 24-h periodicity are generated by the circadian clock, in which clock genes coordinate with one another and form a transcriptional-translational negative feedback loop. The precision of the circadian clock is further regulated by multiple post-translational modifications (PTMs), including phosphorylation, ubiquitination, acetylation and SUMOylation. Here, we review current understanding of the regulatory mechanisms of the core clock proteins by PTMs in the mammalian circadian clock.
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