期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 23, 期 12, 页码 1035-1044出版社
NATURE RESEARCH
DOI: 10.1038/nsmb.3311
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资金
- BBSRC [BB/J0054X/1]
- Wellcome Trust [089156]
- EC FP7 EpiGeneSys
- BBSRC [BB/P00296X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/P00296X/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [1232072] Funding Source: researchfish
Metabolic cycles result from the partitioning of oxidative and reductive metabolism into rhythmic phases of gene expression and oscillating post-translational protein modifications. Relatively little is known about how these switches in gene expression are controlled, although recent studies have suggested that transcription itself may play a central role. This review explores the molecular basis of the metabolic and gene-expression oscillations in the yeast Saccharomyces cerevisiae, as well as how they relate to other biological time-keeping mechanisms, such as circadian rhythms.
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