期刊
JOURNAL OF DIABETES INVESTIGATION
卷 7, 期 4, 页码 459-465出版社
WILEY-BLACKWELL
DOI: 10.1111/jdi.12441
关键词
Type 1 diabetes mellitus; Type 2 diabetes mellitus; Zinc transporter 8
资金
- National Key Technology RD program [2012BAI02B04]
- Hunan Provincial Innovation Foundation for Postgraduate [CX2013B116]
Diabetes can be simply classified into type 1 diabetes mellitus and type 2 diabetes mellitus. Zinc transporter 8 ( ZnT8), a novel islet autoantigen, is specifically expressed in insulin-containing secretory granules of beta-cells. Genetic studies show that the genotypes of SLC30A8 can determine either protective or diabetogenic response depending on environmental and lifestyle factors. The ZnT8 protein expression, as well as zinc content in beta-cells, was decreased in diabetic mice. Thus, ZnT8 might participate in insulin biosynthesis and release, and subsequently involved deteriorated beta-cell function through direct or indirect mechanisms in type 1 diabetes mellitus and type 2 diabetes mellitus. From a clinical feature standpoint, the prevalence of ZnT8A is gradiently increased in type 2 diabetes mellitus, latent autoimmune diabetes in adults and type 1 diabetes mellitus. The frequency and epitopes of ZnT8-specific T cells and cytokine release by ZnT8-specific T cells are also different in diabetic patients and healthy controls. Additionally, the response to ZnT8 administration is also different in type 1 diabetes mellitus and type 2 diabetes mellitus. In the present review, we summarize the literature about clinical aspects of ZnT8 in the pathogenesis of diabetes, and suggest that ZnT8 might play a different role between type 1 diabetes mellitus and type 2 diabetes mellitus.
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