期刊
JOURNAL OF CANCER SURVIVORSHIP
卷 11, 期 1, 页码 1-12出版社
SPRINGER
DOI: 10.1007/s11764-016-0556-1
关键词
Musculoskeletal sarcoma; Survivor; Function; Physical performance; Quality of life; Social role attainment
资金
- National Cancer Institute [CA 21765]
- ALSAC
This study compared measured physical performance, health-related quality of life (HRQOL), and social role attainment between extremity sarcoma survivors and controls, and evaluated associations between disease and treatment exposures, health conditions, and performance measures. Survivors of extremity sarcoma from the St. Jude Lifetime cohort and controls frequency matched by age-, sex-, and race completed physical performance testing and questionnaires. Survivors with Z-scores on outcome measures -2.0 SD (compared to controls) were categorized with severe impairment/limitation. Among 206 survivors (52.4 % male median age 36 years (range 19-65)), 37 % had low relative lean mass, 9.7 % had an ejection fraction < 50 %, 51.5 % had diffusion capacity for carbon monoxide < 75 %, 27.7 % had sensory and 25.2 % motor neuropathy, and 78.2 % had musculoskeletal complications. Severe impairments/limitations were present among ae25 % of survivors on fitness, balance, and physical HRQOL measures, and among ae15 % on strength and activity of daily living measures. Lower extremity tumor location (OR 8.23, 95 % CI 2.54-26.67, P value 0.0004) and amputation (OR 8.07, 95 % CI 3.06-21.27, P value < 0.0001) were associated with poor fitness. Poor fitness was associated with increased odds of scoring < 40 on the SF-36 physical component summary (OR 4.83, 95 % CI 1.95-11.99, P value 0.001) and role-physical subscale (OR 3.34, 95 % CI 1.33-8.43, P value 0.01). Survivors and controls had similar rates of marriage, independent living, employment, and college attendance. Extremity sarcoma survivors experience high rates of physical impairment and report lower than expected physical HRQOL. However, they are as likely as peers to be married, live independently, be employed, and attend college. Follow-up for extremity sarcoma survivors should include assessment of need for further orthopedic care and rehabilitation to address cardiopulmonary and musculoskeletal health.
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