期刊
CLINICAL NEUROPHYSIOLOGY
卷 126, 期 6, 页码 1117-1123出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2014.08.023
关键词
Epileptic foci; Peripheral inhibition; Spike-and-slow waves
资金
- NIH/NINDS [R01NS045207, R01NS058802]
Objective: Experimental epilepsy foci are surrounded by an enhanced inhibition zone. We looked for evidence of peripheral inhibition in human epilepsy foci by analyzing the waveforms of discharges. The sharp-wave of an epileptic discharge is thought to reflect EPSP synchronization, and the subsequent slow-wave to reflect inhibition. Ratios of amplitudes of the sharp-and slow-waves in human EEGs may show how excitatory and inhibitory processes relate to discharge spread implicating peripheral inhibition in human epilepsy, too. Method: In electrocorticography from 10 adult patients we compared amplitudes of sharp-waves and of slow-waves and their ratios in each electrodes as a function of their distance from the highest sharp-wave electrode. Results: Sharp-wave amplitude decreases as a function of electrode distance from the highest sharp-wave electrode, but the slow-wave voltage exhibits a slight increase. The ratio slow-wave/sharp-wave increases several-fold within 2-3 cm from the highest sharp-wave electrode. Conclusion: In human cortex epileptic discharges at the periphery of a focus exhibit a prevalent slowwave consistent with a possible local enhanced inhibition. Significance: Waveform analysis of electrocorticography epileptic discharges suggests the presence in human neocortex of surround inhibition, a basic mechanism limiting the spread of epileptic activity, long studied in experimental models. (C) 2015 Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurophysiology.
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