期刊
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
卷 -, 期 -, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/database/bav120
关键词
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资金
- National Institutes of Health (NIH) [5U41HG007822-02]
- British Heart Foundation [SP/07/007/23671]
- Swiss Federal Government through State Secretariat for Education, Research and Innovation
- Swiss Federal Government through the Federal Office of Education and Science
- British Heart Foundation [SP/07/007/23671] Funding Source: researchfish
Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB.
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