期刊
CELL ADHESION & MIGRATION
卷 11, 期 3, 页码 261-274出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2016.1259059
关键词
Ac2-26; annexin A1; atherosclerosis; cardiovascular diseases; leukocyte recruitment; myocardial infarction; stroke; resolution of inflammation
类别
资金
- Deutsche Forschungsgemeinschaft [SFB914 TP B08, SFB1123 TP A06/B05]
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (VIDI) [91712303]
- Horizon Program (EVOLUTION ITN)
- LMUexcellent program
- Fritz Thyssen Foundation
The inflammatory response protects the human body against infection and injury. However, uncontrolled and unresolved inflammation can lead to tissue damage and chronic inflammatory diseases. Therefore, active resolution of inflammation is essential to restore tissue homeostasis. This review focuses on the pro-resolving molecule annexin A1 (ANXA1) and its derived peptides. Mechanisms instructed by ANXA1 are multidisciplinary and affect leukocytes as well as endothelial cells and tissue resident cells like macrophages and mast cells. ANXA1 has an outstanding role in limiting leukocyte recruitment and different aspects of ANXA1 as modulator of the leukocyte adhesion cascade are discussed here. Additionally, this review details the therapeutic relevance of ANXA1 and its derived peptides in cardiovascular diseases since atherosclerosis stands out as a chronic inflammatory disease with impaired resolution and continuous leukocyte recruitment.
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