期刊
CANCER DISCOVERY
卷 6, 期 3, 页码 235-246出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-15-0893
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资金
- NIH [CA016672, CA109298, UH3TR000943, P50 CA083639, P50 CA098258, CA182905, P50 CA100632, P50 CA097007, P50 CA127001, U54 CA151668, U24 CA143835]
- Cancer Prevention and Research Institute of Texas [RP110595]
- Knowledge GAP MD Anderson grant
- Ovarian Cancer Research Fund, Inc. (Program Project Development Grant)
- Red and Charline McCombs Institute for the Early Detection and Treatment of Cancer
- RGK Foundation
- Duncan Family Institute for Cancer Prevention and Risk Assessment
- Gilder Foundation
- Blanton-Davis Ovarian Cancer Research Program
- Betty Anne Asche Murray Distinguished Professorship
- Alan M. Gewirtz Leukemia & Lymphoma Society Scholar Award
- Russell and Diana Hawkins Family Foundation Discovery Fellowship
miRNAs are a key component of the noncoding RNA family. The underlying mechanisms involved in the interplay between the tumor microenvironment and cancer cells involve highly dynamic factors such as hypoxia and cell types such as cancer-associated fibroblasts and macrophages. Although miRNA levels are known to be altered in cancer cells, recent evidence suggests a critical role for the tumor microenvironment in regulating miRNA biogenesis, methylation, and transcriptional changes. Here, we discuss the complex protumorigenic symbiotic role between tumor cells, the tumor microenvironment, and miRNA deregulation. Significance: miRNAs play a central role in cell signaling and homeostasis. In this article, we provide insights into the regulatory mechanisms involved in the deregulation of miRNAs in cancer cells and the tumor microenvironment and discuss therapeutic intervention strategies to overcome this deregulation. (C) 2016 AACR.
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