期刊
BIOMEDICAL OPTICS EXPRESS
卷 7, 期 10, 页码 4139-4153出版社
Optica Publishing Group
DOI: 10.1364/BOE.7.004139
关键词
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资金
- Australian Research Council
- National Health and Medical Research Council (Australia)
- National Breast Cancer Foundation (Australia)
- Department of Health, Western Australia
- William and Marlene Schrader Trust of The University of Western Australia
Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of similar to 50 x 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving. (C)2016 Optical Society of America
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