期刊
BIOMEDICAL OPTICS EXPRESS
卷 7, 期 9, 页码 3280-3288出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.7.003280
关键词
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资金
- National Institutes of Health [R01CA109558, R01CA167413, R01NS052274]
- CompX Faculty Grant from Institute for Computational Science
Fluorescence guided surgery has the potential to positively impact surgical oncology; current operating microscopes and stand-alone imaging systems are too insensitive or too cumbersome to maximally take advantage of new tumor-specific agents developed through the microdose pathway. To this end, a custom-built illumination and imaging module enabling picomolar-sensitive near-infrared fluorescence imaging on a commercial operating microscope is described. The limits of detection and system specifications are characterized, and in vivo efficacy of the system in detecting ABY-029 is evaluated in a rat orthotopic glioma model following microdose injections, showing the suitability of the device for microdose phase 0 clinical trials. (C)2016 Optical Society of America
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