期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 9, 期 -, 页码 S625-S631出版社
ELSEVIER
DOI: 10.1016/j.arabjc.2011.07.001
关键词
Antimalarial; 4-Aminoquinoline; 1,3,5-Triazine
资金
- All India Council for Technical Education, New Delhi
A novel series of hybrid 4-aminoquinolines- 1,3,5-triazine were synthesized by means of aromatic nucleophilic displacement of chlorine atoms of 2,4,6-trichloro-1,3,5-triazine. Afforded title analogs were subsequently characterised by elemental analysis, FT-IR, H-1 NMR, C-13 NMR and mass spectroscopy and subjected to screening against chloroquine sensitive RKL2 strain of Plasmodium falciparum in 96 well-microtitre plates. However, synthesized derivatives exhibit mild to moderate antimalarial activity and acute toxicity studies of the most active (6a and 6g) compounds were shown to have no significant change in body insight and toxic sign. (C) 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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