4.6 Article

Sequential activation of premotor, primary somatosensory and primary motor areas in humans during cued finger movements

期刊

CLINICAL NEUROPHYSIOLOGY
卷 126, 期 11, 页码 2150-2161

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2015.01.005

关键词

Motor system; Efference copy; Electrocorticography; Forward model; Somatosensory integration; Sensory feedback; Brain computer interface

资金

  1. Christopher Getch Fellowship - Congress of Neurological Surgeons
  2. National Institute of Health (NIH) R01 grant [NS065186-01]
  3. NIH [T90 DA023436-02]
  4. NIH-National Institute of Neurological Disorders and Stroke R25 grant [NS079200]
  5. National Science Foundation grant [EE-1028725]
  6. Keck Foundation

向作者/读者索取更多资源

Objective: Human voluntary movements are a final product of complex interactions between multiple sensory, cognitive and motor areas of central nervous system. The objective was to investigate temporal sequence of activation of premotor (PM), primary motor (M1) and somatosensory (S1) areas during cued finger movements. Methods: Electrocorticography (ECoG) was used to measure activation timing in human PM, S1, and M1 neurons in preparation for finger movements in 5 subjects with subdural grids for seizure localization. Cortical activation was determined by the onset of high gamma (HG) oscillation (70-150 Hz). The three cortical regions were mapped anatomically using a common brain atlas and confirmed independently with direct electrical cortical stimulation, somatosensory evoked potentials and detection of HG response to tactile stimulation. Subjects were given visual cues to flex each finger or pinch the thumb and index finger. Movements were captured with a dataglove and time-locked with ECoG. A windowed covariance metric was used to identify the rising slope of HG power between two electrodes and compute time lag. Statistical constraints were applied to the time estimates to combat the noise. Rank sum testing was used to verify the sequential activation of cortical regions across 5 subjects. Results: In all 5 subjects, HG activation in PM preceded S1 by an average of 53 +/- 13 ms (P = 0.03), PM preceded M1 by 180 +/- 40 ms (P = 0.001) and S1 activation preceded M1 by 136 +/- 40 ms (P = 0.04). Conclusions: Sequential HG activation of PM, S1 and M1 regions in preparation for movements is reported. Activity in S1 prior to any overt body movements supports the notion that these neurons may encode sensory information in anticipation of movements, i.e., an efference copy. Our analysis suggests that S1 modulation likely originates from PM. Significance: First electrophysiological evidence of efference copy in humans. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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