期刊
ACS COMBINATORIAL SCIENCE
卷 18, 期 5, 页码 236-242出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.5b00154
关键词
grinding chemoselective; multicomponent; tetrahydropyridines; solvent-free; catalyst-free
资金
- University Grants Commission, New Delhi under Rajiv Gandhi National Research Fellowship [1420 (Sc)/2009 SA-III]
A highly efficient, chemoselective synthesis of a library of polysubstituted pyrroles and tetrahydropyridines has been achieved through the one-pot, multicomponent reactions of ethyl (E)-3-(aryl/alkyl amino) acrylates, 2,2-dihydroxy-1-arylethan-1-ones, and malononitrile under solvent- and catalyst free grinding conditions. The selective formation of pyrrole or tetrahydropyridines relied on substitution of the N-aryl of ethyl (E)-3-(4-arylamino) acrylates. These reactions presumably occurred via a domino Knoevenagel condensation and Michael addition followed by an intramolecular cyclization sequence of reactions in a single transformation.
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