期刊
ACS CATALYSIS
卷 6, 期 10, 页码 7167-7173出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b02155
关键词
bioisostere design; catalysis; gauche effect; hypervalent iodine; vicinal difluorination
资金
- WWU Munster
- Deutsche Forschungsgemeinschaft [SFB 858]
- Deutsche Forschungsgemeinschaft (Excellence Cluster EXC) [1003]
Contemporaneous reports describing the vicinal difluorination of olefins relying on I(I)/I(III) catalysis have augmented the arsenal of dihalogenation methods and provided a solution to this longstanding challenge in olefin functionalization. In both studies, success was contingent on the in situ generation of ArIF2 from a simple aryl iodide, HF source, and suitable terminal oxidant. The first report by Jacobsen and co-workers employed a resorcinol-derived aryl iodide/m-CPBA oxidant combination, while this laboratory relied on p-iodotoluene and Selectfluor. The complementarity of these approaches ensures that a wide variety of electronically distinct olefins are viable substrates for this transformation. This perspective describes our development of a catalytic difluorination of terminal olefins as a means to efficiently construct a hybrid, chiral bioisostere of the trifluoromethyl and ethyl groups in the broader context of molecular design and highlights key reports from other laboratories that accelerated the study.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据