期刊
ACS CATALYSIS
卷 6, 期 7, 页码 4635-4639出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b00917
关键词
C-H functionalization; indoles; radical addition; cross-coupling hydrogen evolution; photochemistry
资金
- Ministry of Science and Technology of China [2013CB834804, 2014CB239402, 2013CB834505]
- National Natural Science Foundation of China [21390404, 91427303, 21402217]
- Key Research Programme of the Chinese Academy of Sciences [XDB17030201]
- Chinese Academy of Sciences
We describe here an oxidant-free strategy to synthesize indoles, i.e., under visible-light irradiation (lambda = 450 nm), catalytic amounts of an iridium(III) photosensitizer and cobaloxime catalyst transform various N-aryl enamines exclusively into indoles. Our methodology affords indoles in good to excellent yields under mild reaction conditions and produces H-2 as the only byproduct. Spectroscopic and electrochemical studies verify that the designed system proceeds via visible-light-catalyzed oxidation of N-aryl enamines, followed by intramolecular radical addition to yield the indoles smoothly under ambient conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据