期刊
ACS CATALYSIS
卷 6, 期 4, 页码 2368-2371出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b02625
关键词
iridium; asymmetric hydrogenation; 3-hydroxypyridinium salts; piperidin-3-ol; piperidin-3-one
资金
- National Natural Science Foundation of China [21532006, 21372220]
A highly enantioselective hydrogenation of heteroaromatics bearing a hydroxyl group, 3-hydroxypyridinium salts, has been successfully developed using chiral iridium catalyst, providing a direct access to trans 6-substituted piperidin-3-ols with up to 95% ee. Swern oxidation of the hydrogenation products affords chiral 6-substituted piperidin-3-ones, which are easily reduced to cis 6-substituted piperidin-3-ols using K-selectride.
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