期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms10374
关键词
-
资金
- U.S. National Institutes of Health [R21EB013761, P41EB015903, R01CA192878]
- Department of Defense [FA9550-13-1-0068]
- Bullock-Wellman Fellowships
- Marie Curie Career Integration Grant [631679]
- Marie Curie International Outgoing Fellowship within the 7th European Community Framework Programme [627274]
- Human Frontier Science Program (Young Investigator Grant) [RGY0074/2013]
- Bio & Medical Technology Development Program of the National Research Foundation of Korea [2012M3A9C6049791]
- IT Consilience Creative Program of MKE [IITP-2015-R0346-15-1007]
- IT Consilience Creative Program of NIPA [IITP-2015-R0346-15-1007]
- NATIONAL CANCER INSTITUTE [R01CA192878] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB013761, P41EB015903] Funding Source: NIH RePORTER
Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness ( 410 mm) wound closure of porcine skin, which represents similar to 10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据