期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms13029
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资金
- Medical Research Council UK [MR/J004553/1]
- European Research Council [ERC-2012-ADG_20120314]
- Fight For Sight [1448/1449]
- Macular Vision Research Foundation
- Miller's Trust
- Special Trustees of Moorfields Eye Charity
- MRC
- Great Ormond Street Hospital Children's Charity
- National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital
- Department of Health's National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital
- Alcon Research Institute
- MRC [MR/M015688/1, MR/L012758/1, MR/L022699/1, MR/J004553/1] Funding Source: UKRI
- Fight for Sight [1351/52, 1448/49] Funding Source: researchfish
- Great Ormond Street Hospital Childrens Charity [V2816] Funding Source: researchfish
- Medical Research Council [MR/M015688/1, 1074515, MR/L022699/1, MR/L012758/1, MR/J004553/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0515-10069, NF-SI-0513-10074, NF-SI-0508-10130] Funding Source: researchfish
- Rosetrees Trust [M257] Funding Source: researchfish
Photoreceptor replacement by transplantation is proposed as a treatment for blindness. Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to the presence of functional photoreceptors within host retinae that express an array of donor-specific proteins. The resulting improvement in visual function was understood to be due to donor cells integrating within host retinae. Here, however, we show that while integration occurs the majority of donor-reporter-labelled cells in the host arises as a result of material transfer between donor and host photoreceptors. Material transfer does not involve permanent donor-host nuclear or cell-cell fusion, or the uptake of free protein or nucleic acid from the extracellular environment. Instead, RNA and/or protein are exchanged between donor and host cells in vivo. These data require a re-evaluation of the mechanisms underlying rescue by photoreceptor transplantation and raise the possibility of material transfer as a strategy for the treatment of retinal disorders.
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