期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms10982
关键词
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资金
- National Natural Science Foundation of China [31329003, 2012M520923]
- University of Texas Rising STARs award
- University of Texas at MD Anderson Cancer Center start-up fund
- Texas CPRIT grant [RR140071]
- US National Cancer Institute (NCI
- MD Anderson TCGA Genome Data Analysis Center) [CA143883]
- Cancer Prevention Research Institute of Texas (CPRIT) [RP130397]
- Mary K. Chapman Foundation
- Michael and Susan Dell Foundation
- MD Anderson Cancer Center Support Grant [P30 CA016672]
- NIH/NIEHS [R01ES020260]
- NIH/NCI [U01CA180980, R00CA175290]
Mounting evidence suggests that long noncoding RNAs (lncRNAs) can function as microRNA sponges and compete for microRNA binding to protein-coding transcripts. However, the prevalence, functional significance and targets of lncRNA-mediated sponge regulation of cancer are mostly unknown. Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. We confirm the tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. Surprisingly, one of the two lncRNAs, TUG1, was previously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcriptional regulation, suggesting its sub-cellular localization-dependent function. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA.
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