期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/ncomms10740
关键词
-
资金
- Intramural Research Program of the US National Institutes of Health Clinical Center
- National Institute of Allergy and Infectious Diseases
- National Cancer Institute, the National Institutes of Health [HHSN261200800001E]
- National Human Genome Research Institute [U54HG003067]
- National Institutes of Health (NIH/NCRR) [1 P41 RR018502-01]
- Chongqing Medical University (Chongqing, China)
- Public Health Bureau of Guangzhou City [2009-YB-089009]
- Department of Public Health, Guangdong Province, China [2012513]
- China Scholarship Council
Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal pathogen. Here we report near complete genome assemblies for three Pneumocystis species that infect humans, rats and mice. Pneumocystis genomes are highly compact relative to other fungi, with substantial reductions of ribosomal RNA genes, transporters, transcription factors and many metabolic pathways, but contain expansions of surface proteins, especially a unique and complex surface glycoprotein superfamily, as well as proteases and RNA processing proteins. Unexpectedly, the key fungal cell wall components chitin and outer chain N-mannans are absent, based on genome content and experimental validation. Our findings suggest that Pneumocystis has developed unique mechanisms of adaptation to life exclusively in mammalian hosts, including dependence on the lungs for gas and nutrients and highly efficient strategies to escape both host innate and acquired immune defenses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据