期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/ncomms13024
关键词
-
资金
- Singapore A*STAR SERC Public Sector Research Funding (PSF) [R-143-000-618-305]
- National University of Singapore [R-143-000-599-112]
- GSK-EDB [R-143-000-491-592]
The Rauhut-Currier (RC) reaction represents an efficient method for the construction of carbon-carbon bond in organic synthesis. However, the RC reactions involving allenoate substrates are very rare, and in particular, asymmetric intramolecular RC reaction of allenoates is yet to be discovered. Here, we show that the intramolecular RC reaction proceeds smoothly in the presence of 1 mol% beta-ICD, and bicyclic lactones are obtained in high yields and with excellent enantiomeric excesses. With the employment of gamma-substituted allenoates as racemic precursors, a novel dynamic kinetic resolution of allenes via RC reaction is observed, which allows for facile synthesis of highly enantiomerically enriched allenes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据