期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms13633
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资金
- National Basic Research Program of China [2012CB825504]
- National Natural Science Foundation of China [91232720, 31070925]
- Chinese Academy of Sciences (CAS) [GJHZ201302, QYZDY-SSW-SMC015]
- Bill and Melinda Gates Foundation [OPP1119434]
- 100-Talents Program of CAS
- Strategic Priority Research Program of CAS [XDB02040002]
- Bill & Melinda Gates Foundation - Grand Challenges Explorations Initiative [OPP1119434] Funding Source: researchfish
- Bill and Melinda Gates Foundation [OPP1119434] Funding Source: Bill and Melinda Gates Foundation
The brain has an essential role in maintaining a balance between energy intake and expenditure of the body. Deciphering the processes underlying the decision-making for timely feeding of appropriate amounts may improve our understanding of physiological and psychological disorders related to feeding control. Here, we identify a group of appetite-enhancing neurons in a behavioural screen for flies with increased appetite. Manipulating the activity of these neurons, which we name Taotie neurons, induces bidirectional changes in feeding motivation. Long-term stimulation of Taotie neurons results in flies with highly obese phenotypes. Furthermore, we show that the in vivo activity of Taotie neurons in the neuroendocrine region reflects the hunger/satiety states of un-manipulated animals, and that appetitive-enhancing Taotie neurons control the secretion of insulin, a known regulator of feeding behaviour. Thus, our study reveals a new set of neurons regulating feeding behaviour in the high brain regions that represents physiological hunger states and control feeding behaviour in Drosophila.
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