期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 21, 期 2, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2014.08.021
关键词
Drug susceptibility testing; epidemiological cut off; minimal inhibitory concentration; normalised resistance
资金
- Malmo University Hospital
- Department of Clinical Microbiology
- FORSS (The Medical Research Council of Southeast Sweden)
- Swedish Society of Antimicrobial Chemotherapy (SSAC)
- Marianne and Marcus Wallenberg foundation
- Swedish Medical Association
- Karolinska University Hospital
The MIC wild-type (WT) distribution for Mycobacterium tuberculosis in BACTEC 960 MGIT is not defined, which may result in poor reproducibility for drug susceptibility testing (DST), as several DST methods with different breakpoints are in use. In a comparison between MGIT and Middlebrook 7H10 medium of seven first-and second-line drugs, including 133 MIC determinations of 15 WT isolates, we found an agreement of 91.7% within +/- one MIC dilution step. The results confirm the agreement in MIC testing between 7H10 and MGIT and indicate that breakpoints could be harmonized in order to avoid misclassification. Clinical Microbiology and Infection (C) 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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