期刊
ONCOLOGY LETTERS
卷 11, 期 3, 页码 1980-1986出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2016.4168
关键词
PKM2; glycolysis; cancer; metabolic reprogramming; Warburg effect; novel function
类别
资金
- Natural Science Foundation of Jiangsu Province [BK2012482]
- National Natural Science Foundation of China [81472702]
- Jiangsu Province Special Program of Medical Science [BL2012030]
Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis to achieve the nutrient demands of cancer cell proliferation. In addition, the present study discusses the non-metabolic function of PKM2, and its role as a coactivator and protein kinase, which contributes to tumorigenesis. Furthermore, conflicting studies concerning the role of PKM2 as a therapeutic target are reviewed. The improved understanding of PKM2 may provide a noval approach for cancer treatment.
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