期刊
ONCOLOGY LETTERS
卷 12, 期 4, 页码 2445-2450出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2016.4917
关键词
FoxM1; E-cadherin; gastric cancer
类别
资金
- Shanghai Municipal Human Resources and Social Security Bureau (Shanghai, China) [13PJD024]
- Shanghai Health and Family Planning Commission (Shanghai, China) [XYQ2013092]
- Shanghai Municipal Science and Technology Commission (Shanghai, China) [14411966800]
The aim of the present study was to investigate the expression of forkhead box M1 (FoxM1) and E-cadherin in tissues of gastric cancer in order to reveal any correlation between FoxM1, E-cadherin and clinicopathological parameters. The association between FoxM1 and E-cadherin in the development and progression of gastric cancer was also investigated. The expression of FoxM1 and E-cadherin in gastric cancer and adjacent normal tissue on tissue microarray was detected using immunohistochemistry. The clinicopathological significance of FoxM1 and E-cadherin in gastric cancer was explored, and the association between FoxM1 and E-cadherin was further examined using statistical techniques. In gastric cancer tissues, the expression of FoxM1 and E-cadherin was strongly positive, but it was weak in normal gastric mucosa. Overexpression of FoxM1 was evident in gastric cancer, and was associated with poor tumor differentiation (P<0.05), advanced tumor state (P<0.05) and lymph node (or distant) metastasis (P<0.05), whereas E-cadherin had the opposite effects. Furthermore, the correlation between FoxM1 and E-cadherin expression in gastric cancer tissue was negative. In conclusion, the high FoxM1 expression and low E-cadherin expression in gastric cancer tissue suggests that these proteins play a critical role in the development and progression of gastric cancer.
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