期刊
ONCOLOGY LETTERS
卷 12, 期 2, 页码 1355-1360出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2016.4757
关键词
breast cancer; cell cycle; growth factor; tumor stem cells
类别
资金
- China National Natural Scientific Fund, Beijing, China [81471175]
- Tianjin Health Bureau Science and Technology Projects, Tianjin, China [2014KY23]
The majority of cancer stem cells exist in the G0, or quiescent phase of the cell cycle. However, the cells can escape quiescence following routine radiotherapy and chemotherapy, resulting in tumor recurrence. Presently, achieving the accurate regulation of cancer stem cell growth in order to study a specific state, including the quiescent (mostly G0 or G1 phase), proliferative (mostly S phase) or differential (mostly G2/M phase) states, can be challenging. This makes the determination of cell cycle state-specific characteristics and analysis of potential intervention treatments difficult, particularly for quiescent cells. Breast cancer stem cells were cultured on a soft or hard agar matrix surface in the presence or absence of stem cell growth factors. Cells could be successfully limited in either the quiescent, proliferative or differentiated states. These findings provide a foundation for further study of the cell cycle in breast cancer stem cells.
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