期刊
ONCOLOGY LETTERS
卷 11, 期 6, 页码 4066-4068出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2016.4519
关键词
transverse myelopathy; chemotherapy; B-cell acute lymphocytic leukemia
类别
资金
- Foundation of Anhui Medical University [2015xkj018]
- National Natural Science Foundation of China [81401293]
Paraplegia following spinal injury is a rare complication subsequent to the administration of intrathecal chemotherapy; however, it is also one of the rare clinical features of central nervous system leukemia (CNSL). Distinguishing between the two is extremely important. The present study reports the case of a 46-year-old man who was diagnosed with acute lymphoblastic leukemia and subsequently achieved remission in the blood and bone marrow following the initial course of chemotherapy. However, the patient developed a sudden onset of paraplegia and urinary retention due to spinal cord infiltration of leukemia cells following the administration of intrathecal methotrexate and cytarabine. The paraplegia was initially reversible. However, a few weeks later, the patient developed irreversible paraplegia due to a complication of the intrathecal administration of chemotherapy (methotrexate and cytarabine arabinoside). The patient gave up further treatment in May 2013 and succumbed to the disease in June 2013.
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