期刊
ONCOLOGY LETTERS
卷 12, 期 6, 页码 4361-4366出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2016.5292
关键词
non-small cell lung cancer; ovarian metastasis; epidermal growth factor receptor mutation; anaplastic lymphoma receptor tyrosine kinase rearrangement-positive
类别
Ovarian metastasis from non-small cell lung cancer (NSCLC) is a rare condition. The current study presents the cases of 2 female patients aged 38 and 47 years old, respectively, who were initially diagnosed with NSCLC adenocarcinoma on histology. Both patients initially presented with chest pain and a cough, and subsequently developed ovarian metastases following multiple treatments. The 38-year old patient exhibited an epidermal growth factor receptor mutation, confirmed by scorpion/amplified refractory mutation system analysis from a lung biopsy. The 47-year old exhibited an anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangement, revealed by fluorescence in situ hybridization analysis of the break tissue biopsy, confirming a diagnosis of ALK rearrangement-positive NSCLC. These patients developed ovarian metastasis in the course of the disease. The current study reports the diagnostic challenges and clinical management of the disease, and provides a review of the literature.
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