期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 21, 期 3, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2014.10.019
关键词
Atypical serotype; serotype distribution; shift; Shigella; vaccine development
资金
- Mega-projects of Science and Technology Research [2012ZX10004215, 2013ZX10004607, 2013ZX10004218]
- National Nature Science Foundation of China [81373053, 31200942, 81371854, 81202252]
- Beijing Science and Technology Nova programme [xx2013061]
We identified 2912 Shigella isolates from diarrhoeal patients in China during 2003-2013. The most common species was Shigella flexneri (55.3%), followed by Shigella sonnei (44.1%); however, S. sonnei is becoming increasingly prevalent. Among the S. flexneri isolates, serotypes 2a and X variant (-: 7,8, E1037) were the two most prevalent serotypes, and serologically atypical isolates were also commonly identified. Overall, S. sonnei, S. flexneri 2a and S. flexneri X variant (-: 7,8, E1037) accounted for 76.1% of all Shigella isolates, and their prevalence increased from 54.0% during 2003-2004 to 84.1% during 2011-2013. A change was observed in the serotype distribution of Shigella in China during this period, and we propose an ideal strategy to inform the development of a broadly effective Shigella vaccine candidate. Clinical Microbiology and Infection (C) 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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