期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 7, 期 10, 页码 929-932出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.6b00239
关键词
Histone deacetylase; HDAC; histone deacetylase 8; HDAC8; triazole; epigenetic
资金
- Boston University
- Center for Chemical Methodology and Library Development at Boston University [GM-067041]
- NSF [CHE-0619339, CHE- 0443618]
- [R24-GM111625]
A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.
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