期刊
SAUDI PHARMACEUTICAL JOURNAL
卷 24, 期 2, 页码 140-146出版社
ELSEVIER
DOI: 10.1016/j.jsps.2015.01.008
关键词
Mycosynthesis; Nanoparticles; Andrographis paniculata; Colletotrichum sp.; Antibacterial activity
资金
- Department of Science and Technology-Science and Engineering Research Board (DST-SERB)
Mycosynthesis of silver nanoparticles was achieved by endophytic Colletotrichum sp. ALF2-6 inhabiting Andrographis paniculata. Well dispersed nanoparticles were characterized using UV-Visible spectrometry with maximum absorption conferring at 420 nm. FTIR analysis revealed possible biomolecules reducing the metal salt and stabilization of nanoparticles. XRD analysis depicted the diffraction intensities exhibiting between 20 and 80 degrees C at 2theta angle thus conferring the crystalline nature of nanoparticles. Morphological characteristic using TEM revealed the polydispersity of nanoparticles with size ranging from 20 to 50 nm. Synthesized nanoparticles exhibited bactericidal activity against selected human pathogens. Nanoparticles mode of action was carried out to reveal DNA damage activity. Thus the present investigation reports facile fabrication of silver nanoparticles from endophytic fungi. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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