期刊
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
卷 9, 期 4, 页码 257-265出版社
SPRINGER
DOI: 10.1007/s12265-016-9693-1
关键词
Electrocardiography; Vectorcardiography; Cardiac mapping; Cardiac resynchronization therapy; Left bundle-branch block
资金
- Project COHFAR (Congestive Heart Failure and Arrhythmia [01C-203]
- Dutch Heart Foundation
Cardiac resynchronization therapy (CRT) is a well-known treatment modality for patients with a reduced left ventricular ejection fraction accompanied by a ventricular conduction delay. However, a large proportion of patients does not benefit from this therapy. Better patient selection may importantly reduce the number of non-responders. Here, we review the strengths and weaknesses of the electrocardiogram (ECG) markers currently being used in guidelines for patient selection, e.g., QRS duration and morphology. We shed light on the current knowledge on the underlying electrical substrate and the mechanism of action of CRT. Finally, we discuss potentially better ECG-based biomarkers for CRT candidate selection, of which the vectorcardiogram may have high potential.
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