期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 8, 期 7, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a018853
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资金
- German Research Foundation (DFG) [SFB 870]
- Synergy Excellence Cluster
- ICEMED Helmholtz Alliance
- European Research Commission (ERC) Grant ChroNeuroRepair [340793]
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) [2R01NS06989306]
- European Research Council (ERC) [340793] Funding Source: European Research Council (ERC)
Adult neurogenesis in the mammalian brain is often viewed as a continuation of neurogenesis at earlier, developmental stages. Here, we will critically review the extent to which this is the case highlighting similarities as well as key differences. Although many transcriptional regulators are shared in neurogenesis at embryonic and adult stages, recent findings on the molecular mechanisms by which these neuronal fate determinants control fate acquisition and maintenance have revealed profound differences between development and adulthood. Importantly, adult neurogenesis occurs in a gliogenic environment, hence requiring adult-specific additional and unique mechanisms of neuronal fate specification and maintenance. Thus, a better understanding of the molecular logic for continuous adult neurogenesis provides important clues to develop strategies to manipulate endogenous stem cells for the purpose of repair.
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