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A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals
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Primary cilia are required in a unique subpopulation of neural progenitors
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A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a
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CELL REPORTS (2014)
Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling
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PLOS GENETICS (2014)
The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport
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ELIFE (2014)
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AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Defects in the IFT-B Component IFT172 Cause Jeune and Mainzer-Saldino Syndromes in Humans
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AMERICAN JOURNAL OF HUMAN GENETICS (2013)
The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling
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GENES & DEVELOPMENT (2013)
The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia
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Centrosomal Protein DZIP1 Regulates Hedgehog Signaling by Promoting Cytoplasmic Retention of Transcription Factor GLI3 and Affecting Ciliogenesis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification
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Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
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Mutations in C5ORF42 Cause Joubert Syndrome in the French Canadian Population
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AMERICAN JOURNAL OF HUMAN GENETICS (2012)
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AMERICAN JOURNAL OF HUMAN GENETICS (2012)
The Spinocerebellar Ataxia-Associated Gene Tau Tubulin Kinase 2 Controls the Initiation of Ciliogenesis
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Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates
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Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation
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TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum
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A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition
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Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components
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Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract
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PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals
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Electron-tomographic analysis of intraflagellar transport particle trains in situ
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Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
Stephanie L. Bielas et al.
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Dual and opposing roles of primary cilia in medulloblastoma development
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Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis
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Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
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The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling
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Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome
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C2cd3 is required for cilia formation and Hedgehog signaling in mouse
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Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
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Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool
N. Spassky et al.
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THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
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Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
Young-Goo Han et al.
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Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain
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Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11
Henry Houlden et al.
NATURE GENETICS (2007)
Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism
Eric Dessaud et al.
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Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool
Victor V. Chizhikov et al.
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Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia
Victor L. Ruiz-Perez et al.
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Patched1 regulates Hedgehog signaling at the primary cilium
Rajat Rohatgi et al.
SCIENCE (2007)
Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis
Eiki Koyama et al.
DEVELOPMENT (2007)
RAB23 mutations in carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity
Dagan Jenkins et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
The graded response to sonic hedgehog depends on cilia architecture
Tamara Caspary et al.
DEVELOPMENTAL CELL (2007)
Intraflagellar transport is essential for endochondral bone formation
Courtney J. Haycraft et al.
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Hippi is essential for node cilia assembly and Sonic hedgehog signaling
Caroline Houde et al.
DEVELOPMENTAL BIOLOGY (2006)
Analysis of Nsdhl-deficient embryos reveals a role for hedgehog signaling in early placental development
Fenglei Jiang et al.
HUMAN MOLECULAR GENETICS (2006)
MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome
M Kyttälä et al.
NATURE GENETICS (2006)
Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification
MI Ferrante et al.
NATURE GENETICS (2006)
Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition
JF Reiter et al.
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Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
SR May et al.
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Vertebrate Smoothened functions at the primary cilium
KC Corbit et al.
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Gli2 and Gli3 localize to cilia and require the intra-flagellar transport protein polaris for processing and function
CJ Haycraft et al.
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Cilia and Hedgehog responsiveness in the mouse
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Genetic regulation of stem cell origins in the mouse embryo
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Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
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A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size
J Bond et al.
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Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning
S Ahn et al.
CELL (2004)
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
BD Harfe et al.
CELL (2004)
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
CB Bai et al.
DEVELOPMENTAL CELL (2004)
The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification
E Bonnafe et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Hedgehog signalling in the mouse requires intraflagellar transport proteins
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Mutations in two nonhomologous genes in a head-to-head configuration cause Ellis-van Creveld syndrome
VL Ruiz-Perez et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2003)
The ultrastructure of primary cilia in the endocrine and excretory duct cells of the pancreas of mice and rats
AA Aughsteen
EUROPEAN JOURNAL OF MORPHOLOGY (2001)
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JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH (2001)
Polarized dendritic transport and the AP-1 μ1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia
ND Dwyer et al.
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Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
JT Eggenschwiler et al.
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Identification of the gene for oral-facial-digital type I syndrome
MI Ferrante et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Specification of neuronal fates in the ventral neural tube
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Localization of 5-HT6 receptors at the plasma membrane of neuronal cilia in the rat brain
I Brailov et al.
BRAIN RESEARCH (2000)