期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 9, 期 3, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a028720
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资金
- Swiss National Science Foundation Grant [31003A-153340]
- European Research Council Grant [ERC-2010-StG-260667]
- Ecole Polytechnique de Lausanne
- Natural Sciences and Engineering Research Council of Canada Postgraduate Studies Doctoral scholarship
- Swiss National Science Foundation (SNF) [31003A_153340] Funding Source: Swiss National Science Foundation (SNF)
Mammals have evolved an internal timing system, the circadian clock, which synchronizes physiology and behavior to the daily light and dark cycles of the Earth. The master clock, located in the suprachiasmatic nucleus (SCN) of the brain, takes fluctuating light input from the retina and synchronizes other tissues to the same internal rhythm. The molecular clocks that drive these circadian rhythms are ticking in nearly all cells in the body. Efforts in systems chronobiology are now being directed at understanding, on a comprehensive scale, how the circadian clock controls different layers of gene regulation to provide robust timing cues at the cellular and tissue level. In this review, we introduce some basic concepts underlying periodicity of gene regulation, and then highlight recent genome-wide investigations on the propagation of rhythms across multiple regulatory layers in mammals, all the way from chromatin conformation to protein accumulation.
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