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Polycomb silencers control cell fate, development and cancer
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Polycomb complexes repress developmental regulators in murine embryonic stem cells
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The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions
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A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells
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Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
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Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
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The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
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Regulation of p53 activity through lysine methylation
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Role of histone H2A ubiquitination in polycomb silencing
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The SWIB and the MDM2 domains are homologous and share a common fold
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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
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p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
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