期刊
JOURNAL OF FUNCTIONAL FOODS
卷 21, 期 -, 页码 104-112出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.11.037
关键词
Oat; beta-(1-3,1-4) Glucan; Dectin-1; Particle size; Endo-glucanase; Dendritic cells
资金
- Carbohydrate Competence Center [CCCWP24]
- European Union
- European Regional Development Fund
- Northern Netherlands Provinces (Samenwerkingsverband Noord-Nederland), KOERS NOORD
Oat beta-Glucans were studied for their immunological impact before and after enzymatic digestion in order to enhance the efficacy of oat beta-Glucans for application in functional foods. Oat beta-Glucan is reported to have minimal impact compared to its fungal counterpart in vitro. Digestion with endo-glucanase enhanced its efficacy towards stimulating MCP-1, RANTES, IL-8, and IL-4 production in human dendritic cells as compared to the nondigested beta-Glucan. This effect resulted from an enhanced activation of the Dectin-1 receptor. Our data suggest that the immune-stimulation was dependent on the beta-(1-3) linkages and the reduced particle size of digested beta-Glucans. Thus, we show that enzymatic pre-digestion of dietary fibres such as oat beta-Glucan enhances its impact on specific immune receptors. We also demonstrate that particle size and/or molecular weight of oat beta-Glucans and exposure of specific binding sites for the receptors might be important tools for designing efficacious functional feed and food additives. (C) 2015 Elsevier Ltd. All rights reserved.
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