期刊
JOURNAL OF FUNCTIONAL FOODS
卷 22, 期 -, 页码 20-33出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.01.010
关键词
Metabolomics; L-arginine; Hypertension; Biomarkers; Phospholipids; Tocopherol
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-249890-13, RGPIN-2014-04815]
Plasma and urine metabolomics profiles of spontaneously hypertensive rats (SHRs) fed with chicken skin protein hydrolysates (CSPHs) were investigated to establish possible biomarkers of blood pressure regulation. SHR and wistar Kyoto (WKY) rats were randomised into groups that received casein-only (control), CSPHs (0.5 or 1%) or chicken skin meal (CSM 1%) diets for six weeks. Results showed that the diets significantly (P < 0.05) lowered systolic blood pressure (SBP) of SHRs (-36, -31 and -26 mmHg for CSPH 1%, CSPH 0.5% and CSM 1%, respectively) but not WKY. This correlated with decreased plasma angiotensin converting enzyme levels but not with superoxide dismutase activity. Partial least square discrimination analysis of detected metabolites in urine and plasma of rats showed significant changes in levels of symmetric dimethylarginine, N-2-acetyl-L-omithine, buthionine sulfoximine, uric acid, a-tocopherol succinate, L-isoleucine, creatinine, and phospholipids. CSPHs could therefore be used as ingredients in developing nutraceuticals and functional foods for hypertension management. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据