期刊
JOURNAL OF FUNCTIONAL FOODS
卷 20, 期 -, 页码 245-252出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.10.021
关键词
GSE; Jejunum; Differentiation; IL-10-deficient mice; Inflammation; Alkaline phosphatase
资金
- Washington State University [118887]
The effects of dietary grape seed extract (GSE) on protecting jejunum epithelial were investigated using interlukin-10-deficient mice. GSE supplementation increased villus length, mucosal thickness and enhanced goblet cell density associated with enhanced expression of villin and two key differentiation transcription factors, Hairy/Enhancer of Split 1 (Hest) and Kruppel-Like Factor-4 (Klf4), and increased p21 (CIP1/WAF1) content. Additionally, expression of nutrient transporters, alanyl aminopeptidase and glucose transporter-2 were increased in GSE supplemented jejunum. Consistent with its anti-inflammatory effects, GSE supplementation decreased tumor necrosis factor-a and interferon-gamma expression and down regulated NF-kappa B signalling. Furthermore, GSE decreased total alkaline phosphatase activity with a concomitant increase in intestinal alkaline phosphatase protein. Thus, GSE improves jejunum health in interlukin10-deficient mice likely through suppressing inflammation and regulating alkaline phosphatase. Published by Elsevier Ltd.
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