4.7 Article

Grape seed flavanols decrease blood pressure via Sirt-1 and confer a vasoprotective pattern in rats

期刊

JOURNAL OF FUNCTIONAL FOODS
卷 24, 期 -, 页码 164-172

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.03.030

关键词

Endothelial nitric oxide synthase; Endothelin-1; Flavanols; Hypertension; NADPH oxidase; Nitric oxide

资金

  1. Spanish Government [AGL2013-40707-R]
  2. Universitat Rovira i Virgili [DL003693]
  3. Fundacio Caixa Tarragona of CatalunyaCaixa [2011BRDI-06-28]

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Involvement of nitric oxide (NO) in the antihypertensive effect of grape seed flavanols was previously demonstrated. This study investigates the endothelial vasoprotective pattern and the role of Sirtuin-1 (Sirt-1) in this antihypertensive effect. Cafeteria diet-fed hypertensive rats (CHR) were administered water or 375 mg/kg of a low-molecular grape seed polyphenol extract (LM-GSPE) rich in flavanols and sacrificed 6 h post-administration. Plasma endothelin-1 (ET-1) and aortic expression of NO pathway genes, NADPH oxidase subunit 4 (NOX4) and ET-1 genes were measured. LM-GPSE decreased plasma ET-1, upregulating eNOS and Sirt-1 and downregulating aortic gene expression of ET-1 and NADPH, the endothelial major producer of free radicals, indicating the vasoprotective effect of grape seed flavanols. Additionally, twenty-four spontaneously hypertensive rats (SHR) were administered water or 375 mg/kg LM-GSPE and treated with 1 mg/kg sirtinol (inhibitor of Sirt-1). The antihypertensive effect of LM-GSPE was completely abolished by sirtinol, indicating that grape seed flavanols decrease BP in a Sirt-1-dependent manner. (c) 2016 Elsevier Ltd. All rights reserved.

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