期刊
JOURNAL OF FUNCTIONAL FOODS
卷 20, 期 -, 页码 556-566出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.11.002
关键词
Development; Drosophila; Green tea; Reproduction; Toxicity
资金
- National Institutes of Health [R21AT004987]
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [R21AT004987] Funding Source: NIH RePORTER
Although green tea has numerous health benefits, adverse effects with excessive consumption have been reported. Using Drosophila melanogaster, a decrease in male fertility with green tea was evidenced. Here, the extent of green tea toxicity on development and reproduction was investigated. Drosophila melanogaster embryos and larvae were exposed to various doses of green tea polyphenols (GTP). Larvae exposed to 10 mg/mL GTP were slower to develop, emerged smaller, and exhibited a dramatic decline in the number of emerged offspring. GTP protected flies against desiccation but sensitised them to starvation and heat stress. Female offspring exhibited a decline in reproductive output and decreased survival while males were unaffected. GTP had a negative impact on reproductive organs in both males and females (e.g., atrophic testes in males, absence of mature eggs in females). Collectively, the data show that high doses of GTP adversely affect development and reproduction of Drosophila melanogaster. (C) 2015 Elsevier Ltd. All rights reserved.
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