期刊
JOURNAL OF FUNCTIONAL FOODS
卷 20, 期 -, 页码 516-531出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.11.029
关键词
Pacific oyster; Obesity; Insulin resistance; Polyphenol; Antioxidant
资金
- Japan Society for the Promotion of Science [25450297]
- Regional Innovation Strategy Support Program of the MEXT (Ministry of Education, Culture, Sports, Science, and Technology, Japan)
The phenolic compound 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) is a natural antioxidant recently isolated from the Pacific oyster. DHMBA, up to a concentration of 500 mu M, has demonstrated a strong in vitro hepatocyte-protective effect from oxidative stress without any cytotoxicity. This study investigated the in vivo potential of DHMBA-rich oyster extracts (DOE) for prevention or attenuation of non-alcoholic steatohepatitis (NASH). NASH-model mice, developed by supplementation of a high-fat diet for 23 weeks and intravenous injections of oxidised low-density lipoproteins, exhibited obesity, insulin resistance, hepatic steatosis, inflammation, fibrosis, and apoptosis. These changes were significantly moderated by supplementation of DOE. The search for an underlying mechanism determined that DOE significantly improved the redox status of DNA, proteins, and lipids. Moreover, DOE suppressed the increase of hepatic expression of PPARy and CD36 (fatty acid transporter) in the NASH-model mice. DOE might serve as a functional food for people at elevated risk for NASH. (C) 2015 The Authors. Published by Elsevier Ltd.
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