期刊
JOURNAL OF FUNCTIONAL FOODS
卷 27, 期 -, 页码 274-294出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.09.014
关键词
Beer; Antigenotoxicity; Drosophila melanogaster; Tumour cells; Cytotoxicity; Macroautophagy
The aim of the present study was to examine the nutraceutic potential of lyophilised blond Lager beer, as well as two of its bioactive components: xanthohumol and folic acid. Several toxicity, antitoxicity, genotoxicity, antigenotoxicity and longevity endpoints were checked in the SMART in vivo Drosophila system. Cytotoxicity in HL-60 promyelocytic and NIH3T3 mouse fibroblasts cells, proapototic DNA fragmentation, comet assay, macroautophagy activity and methylation status were tested in in vitro assays. Lyophilised blond Lager beer could be proposed as a substance with an important nutraceutical value, because of its hopeful results as a lifespan promoter, DNA protection against free radicals in the animal model and its chemopreventive activity in HL-60 cells and enhacer of macroautophagy at moderate doses in NIH3T3 inmortal cells. Only xanthohumol mimics the biological activities found in lyophilised beer. (C) 2016 Elsevier Ltd. All rights reserved.
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