期刊
MEDCHEMCOMM
卷 7, 期 6, 页码 1171-1175出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6md00104a
关键词
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资金
- National Natural Science Foundation of China [21236002]
- National High Technology Research and Development Program of China (863 Program) [2011AA10A207]
- Fundamental Research Funds for the Central Universities
A novel single and small molecular theranostic agent (1a) based on a naphthalimide dye has been developed and characterized. The agent (1a) displays excellent fluorescence for cell imaging (fluorescent quantum yields of 0.81) and photodynamic effects for therapeutic effectiveness (micromolar inhibition efficacy in vitro towards a broad spectrum of tumor models and anticancer treatment in vivo on A375 tumor xenograft models). This provides a new approach for simultaneous improvement in two directions using a small molecule as theranostic agent, which usually are in conflict with each other for most traditional theranostic agents.
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