期刊
MEDCHEMCOMM
卷 7, 期 11, 页码 2076-2082出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6md00371k
关键词
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资金
- NSF [0959360]
- NIH-NIAID [AI083803, AI062182, AI068159]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0959360] Funding Source: National Science Foundation
We report the synthesis of two novel pyrrole-imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing human papillomavirus strains. Introduction of guanidinium improves antiviral activity when compared to an unsubstituted analog, especially in IC90 values. These substitutions change DNA-binding preferences, while binding affinity remains unchanged.
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