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Analysis of biofluids by paper spray MS: advances and challenges

期刊

BIOANALYSIS
卷 8, 期 6, 页码 589-606

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FUTURE SCI LTD
DOI: 10.4155/bio-2015-0018

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ambient ionization; chromatography; DBS; direct analysis; dried matrix spots; dried plasma spots; dried urine spots; ion mobility

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Paper spray MS is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma and urine spots at the low ng/ml to pg/ml levels without sample preparation. No front end separation is performed, so MS/MS or high-resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique and discuss some of its limitations.

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