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Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis

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FRONTIERS IN NEURAL CIRCUITS
卷 10, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2016.00066

关键词

orexin; posterior lateral hypothalamic area; neuroendocrine control; HPT axis; autonomic functions

资金

  1. Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples
  2. Department of Experimental Medicine, Second University of Naples

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Hypocretin/orexin (ORX) are two hypothalamic neuropeptides discovered in 1998. Since their discovery, they have been one of the most studied neuropeptide systems because of their projecting fields innervating various brain areas. The orexinergic system is tied to sleep-wakefulness cycle, and narcolepsy is a consequence of their system hypofunction. Orexinergic system is also involved in many other autonomic functions such as feeding, thermoregulation, cardiovascular and neuroendocrine regulation. The main aim of this mini review article is to investigate the relationship between ORX and thyroid system regulation. Although knowledge about the ORX system is evolving, its putative effects on hypothalamic-pituitary-thyroid (HPT) axis still appear unclear. We analyzed some studies about ORX control of HPT axis to know better the relationship between them. The studies that were analyzed suggest Hypocretin/ORX to modulate the thyroid regulation, but the nature (excitatory or inhibitory) of this possible interaction remains actually unclear and needs to be confirmed.

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