4.2 Article

Tosylimidazole-mediated one-pot synthesis of 2-azetidinones

期刊

JOURNAL OF CHEMICAL RESEARCH
卷 -, 期 9, 页码 532-534

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SAGE PUBLICATIONS LTD
DOI: 10.3184/174751916X14683354026584

关键词

beta-lactam; 2-azetidinone; Staudinger reaction; tosylimidazole; ketene; imine

资金

  1. Payame Noor University Research Council

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Cyclocondensation of Schiff bases and substituted acetic acid with tosylimidazole afforded 2-azetidinones in good to excellent yields. This reaction works reliably well for monocyclic and spirocyclic 2-azetidinones. This reaction is green and efficient and the products can be purified by simple crystallisation.

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