4.2 Article

An efficient preparation of novel epoxyketone intermediates for the synthesis of carfilzomib and its derivatives

期刊

JOURNAL OF CHEMICAL RESEARCH
卷 -, 期 2, 页码 82-86

出版社

SAGE PUBLICATIONS LTD
DOI: 10.3184/174751916X14539789662063

关键词

carfilzomib; epoxyketone derivatives; vanadium(III) acetylacetonate

资金

  1. National Natural Science Foundation of China [21302097]
  2. Natural Science Fund for Colleges and Universities in Jiangsu Province [14KJD350002]
  3. Technology Support Programme of the Science and Technology Department of Jiangsu Province [BE2014720]
  4. National and Local Joint Engineering Research Centre of Biomedical Functional Materials
  5. Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

向作者/读者索取更多资源

A novel and efficient preparation of epoxyketone intermediates for the synthesis of carfilzomib and its derivatives has been developed. Compared to reported methods, this highly stereoselective, environmentally friendly, low-cost method can be used in scaling up the synthesis of carfilzomib and its derivatives.

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