期刊
JOURNAL OF CHEMICAL RESEARCH
卷 -, 期 2, 页码 82-86出版社
SAGE PUBLICATIONS LTD
DOI: 10.3184/174751916X14539789662063
关键词
carfilzomib; epoxyketone derivatives; vanadium(III) acetylacetonate
资金
- National Natural Science Foundation of China [21302097]
- Natural Science Fund for Colleges and Universities in Jiangsu Province [14KJD350002]
- Technology Support Programme of the Science and Technology Department of Jiangsu Province [BE2014720]
- National and Local Joint Engineering Research Centre of Biomedical Functional Materials
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
A novel and efficient preparation of epoxyketone intermediates for the synthesis of carfilzomib and its derivatives has been developed. Compared to reported methods, this highly stereoselective, environmentally friendly, low-cost method can be used in scaling up the synthesis of carfilzomib and its derivatives.
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